Intratubular Renin-Angiotensin System in Hypertension
نویسندگان
چکیده
منابع مشابه
Intratubular renin-angiotensin system in hypertension.
It is well recognized that the renin-angiotensin system plays an important role in the regulation of arterial pressure and sodium homeostasis. Recent years, many studies have shown that local tissue angiotensin II levels are differentially regulated and cannot be explained on the basis of circulating concentrations. All of the components needed for angiotensin II generation are present within t...
متن کاملBrief Reviews Intratubular Renin-Angiotensin System in Hypertension
The complexity of the intrarenal renin-angiotensin (Ang) system (RAS) continues to reveal itself as evidence accumulates demonstrating its robust independent regulation in the interstitial and intratubular compartments within the kidney.1–3 Early reports demonstrating the presence of Ang II receptors on the brush border of proximal tubules suggested physiological roles.4 However, because of the...
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Various models of experimental hypertension and clinical examples of increased renin formation from a stenotic kidney or a juxtaglomerular cell tumor have shown that increased circulating angiotensin II (Ang II) stimulates the intrarenal/intratubular renin-angiotensin system (RAS) that elicits renal vasoconstriction, enhanced tubular sodium reabsorption, and progressive development of hypertens...
متن کاملThe increasing complexity of the intratubular Renin-Angiotensin system.
The presence of receptors for angiotensin II (AII) on the luminal membranes of various nephron segments has been well established for many decades. Originally their function remained unclear because tubular fluid AII concentrations were thought to be quite low due to the presence of various degrading enzymes on the brush border of proximal tubular cells. However, a series of reports in the 1990...
متن کاملHypertension and Renin-Angiotensin System
The renin-angiotensin system (RAS) participates in numerous biological activities. Among these is the pathophysiological mechanisms of hypertension, congestive heart failure, myocardial infarction, diabetic nephropathy and inflammatory disorders. These pleiotropic effects led to the development of new therapeutic approaches to inhibit the actions of this system. This chapter aims to relate the ...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2011
ISSN: 0194-911X,1524-4563
DOI: 10.1161/hypertensionaha.110.163519